Home | Active vs Passive Hemostasis
Fast-acting1,b hemostasis Thrombin-JMI® is a biologically active hemostat that gets to the site of bleeding.
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The Choice For Thrombin-JMI® Learn more about the importance of choosing an active and fast-acting1,b topical hemostat.
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The delivery options you need Thrombin-JMI® provides fast,1,b effective hemostasis where you want it, when you need it.
Learn about the multiple delivery options of thrombin

Active vs Passive Hemostasis

Active hemostats act directly in the coagulation cascade. Passive hemostats promote platelet aggregation.7

 

There are a number of topical hemostatic agents for use in surgery. Tissue sealants and glues are appropriate for certain procedures and types of bleeding, while other topical hemostats are suitable for minor bleeding.8

 

Among the topical hemostats for minor bleeding and oozing blood, the products can be divided into 2 groups—those that act directly in the coagulation cascade and those that act passively through contact activation and promotion of platelet aggregation.7

 

Passive Hemostats—Acting as a Scaffold

  • May be more useful in profuse hemorrhage8
  • Often need to be removed prior to closure of surgical site9
  • Requires fully functional clotting mechanism8

 

Active Hemostats—Directly Involved in Coagulation Cascade

  • Bypass the initial enzymatic steps of the coagulation cascade2,10
  • Concentration by units allows for adjustability2
  • Indicated for use in oozing blood and minor bleeding from capillaries and small venules2
  • Systemic injection could result in extensive intravascular clotting or even death2
  • Potential for development of inhibiting antibodies that may interfere with hemostasis2

 

 

Combining Thrombin-JMI® with passive hemostats

 

Whereas passive agents largely provide a barrier scaffold for the aggregation of platelets and subsequent soft clot formation, active hemostats are directly involved in the coagulation cascade to induce a clot at the site of oozing blood and minor bleeding.7 Active hemostats can be combined with certain passive hemostats.11,a

 

Passive and Active Hemostat Classification Chart

 

 

a Please see the full Prescribing Information of the Absorbable Gelatin Sponge, USP or hemostatic agent used.
b Time to hemostasis is dependent on the concentration of both thrombin and fibrinogen.