Thrombin-JMI® (Thrombin, Topical, Bovine Origin, U.S.P.) Delivery Options


	The Choice For Thrombin-JMI^® Learn more about the importance of choosing an active and fast-acting¹^,c topical hemostat. View the clinical data Fast-acting¹^,c hemostasis Thrombin-JMI^® is a biologically active hemostat that gets to the site of bleeding. Learn how Thrombin-JMI^® works See Thrombin-JMI^® In Use Orthopedic surgery Neurosurgery Vascular and thoracic surgery

Delivery Options

For Operating Room (Or) Procedures

As an aid to hemostasis

Thrombin-JMI^® Pump Spray Kit: to cover broad oozing areas

Omnidirectional spray
360° coverage
Sterile inner tray suitable for most operating fields

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Thrombin-JMI^® Syringe Spray Kit: for difficult-to-reach bleeding sites^a

Responds to touch—light for stream, heavy for wide mist
15°-Angle tip that allows for precise application
Sterile inner tray is suitable for introduction into operating fields

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Thrombin-JMI^® Vials: for direct application or use in conjunction with certain passive hemostats^2,^b

Dry powder (lyophilized) or reconstituted for direct application²
Can be used with certain passive hemostats

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For control of surface bleeding as a temporary external dressing²

Thrombi-Gel^® (thrombin/gelatin foam hemostat): 2-in-1 composite of thrombin and gelatin foam

Consists of thrombin freeze-dried into a gelatin foam
Packaged sterile in a foil pouch with an inner tray
Can be used as temporary trauma dressing for active topical hemostasis

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For Emergency Department (ED) Procedures

Thrombi-Pad™ (3x3 hemostatic pad): active hemostasis for active bleeding

Composite of thrombin and a gauze pad
Contains lyophilized thrombin, sodium carboxymethylcelluose, and calcium chloride in nonwoven gauze
Can be used as trauma dressing for active topical hemostasis

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Thrombin-JMI^® Epistaxis Kit: active hemostat delivered as nasal spray for the treatment of epistaxis

Nasal drug delivery device designed to provide reliable atomization and even delivery of topical solution in a fine, mist-like spray targeted to the nasal mucosal region

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^a Do not inject or allow to enter large blood vessels.
^b Please see the full Prescribing Information of the Absorbable Gelatin Sponge, USP or hemostatic agent used.
^c Time to hemostasis is dependent on the concentration of both thrombin and fibrinogen.

Thrombin-JMI^® is indicated as an aid to hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible. In various types of surgery, solutions of Thrombin-JMI^® may be used in conjunction with an Absorbable Gelatin Sponge, USP for hemostasis.

Thrombi-Pad™ (3x3 hemostatic pad) is applied topically and is indicated as a trauma dressing for temporary control of moderate to severely bleeding wounds and for the control of surface bleeding from vascular access sites and percutaneous catheters and tubes. Please see the Instructions for Use.

Thrombi-Gel^® (thrombin/gelatin foam hemostat) is applied topically and is indicated as a trauma dressing for temporary control of moderate to severely bleeding wounds and for the control of surface bleeding from vascular access sites and percutaneous catheters and tubes. Please see the Instructions for Use.

Important Safety Information
Because of its action in the clotting mechanism, Thrombin-JMI^® must not be injected or otherwise allowed to enter large blood vessels. Extensive intravascular clotting and even death may result.

Occasionally, the use of topical bovine thrombin preparations has been associated with abnormalities in hemostasis ranging from alterations in prothrombin time (PT) and partial thromboplastin time (PTT) to severe bleeding or thrombosis. These hemostatic effects have rarely been fatal and appear to be related to the formation of cross-reacting bovine antibodies to thrombin and/or factor V. Consultation with an expert in coagulation disorders is recommended if a patient exhibits any of these abnormalities following the use of topical thrombin, particularly following repeat application. Any interventions should consider the immunologic basis of this condition. Patients with antibodies to bovine thrombin preparations should not be re-exposed to these products.

Thrombin-JMI^® should be given to a pregnant woman only if clearly indicated. Safety and effectiveness in children have not been established.

For additional Important Safety Information, please see the full Prescribing Information.

ThrombiGel is a registered trademark of Vascular Solutions, Inc. Thrombin-JMI^® and Thrombi-Pad^™ are trademarks
of King Pharmaceuticals Research and Development, Inc., a wholly owned subsidiary of King Pharmaceuticals^®, Inc.
All other trademarks, registered or unregistered, are the property of their respective owners.

Copyright © 2008, King Pharmaceuticals^®, Inc. All rights reserved. JMI4986 02/2008
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